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Charles de Lorraine, duc de Mayenne (26 March 1554 - 3 October 1611) was a French noble, governor, military commander and rebel during the latter French Wars of Religion. Born in 1554, the second son of François de Lorraine, duke of Guise and Anne d'Este, Mayenne inherited his fathers' position of Grand Chambellan in 1563 upon his death.

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