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Demerara-Mahaica (Region 4) is a region of Guyana. It hosts Georgetown, the capital and largest town of Guyana. Located between the Mahaica, Demerara, and Moblissa rivers, it is spread over an area of 2232 km2, and is the smallest region by area in Guyana. As per the 2022 census, it had a population of 347,759, the highest of all the regions.

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