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Z-RNA is a left-handed alternative conformation for the RNA double helix. Just like for Z-DNA, Z-RNA is favored by a sequence composed of Purine/Pyrimidine repeats and especially CG repeats.

Discovery

The ability of dsRNA to convert into a left-handed helix was demonstrated using NMR and circular dichroism in 1984. This conversion was shown to require high ionic strength and elevated

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