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Z-DNA-binding protein 1 (also known as DNA-dependent activator of IFN-regulatory factors (DAI) and DLM-1) is an intracellular protein in mammals that can activate an innate immune pathways to suppress the viral infection. ZENB1 senses left-handed (Z-form) double-helical Z-DNA and Z-RNA, which are pathogen-associated molecular patterns (PAMPs). It associates with

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