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<p><b>Malignant transformation</b> is the process by which cells acquire the properties of <a href="page.php?w=cancer">cancer</a>. This may occur as a primary process in normal tissue, or secondarily as malignant degeneration of a previously existing <a href="page.php?w=benign_tumor">benign tumor</a>.</p>

<p><big>Causes of cancer</big></p>
<p>There are many causes of primary malignant transformation, or <a href="page.php?w=tumorigenesis">tumorigenesis</a>.  Most human cancers in the United States are caused by external factors, and these factors are largely</p><p>
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