kidney epithelial cells, and the brain).

"This conversion reduces the peptide from ten amino acids (angiotensin I) to eight amino acids (angiotensin II), with the removal of the terminal His-Leu dipeptide by ACE."

Degradation

Angiotensin II is degraded to angiotensin III by angiotensinases located in red blood cells and the vascular beds of most tissues. Angiotensin II has a half-life in circulation of around 30 seconds, whereas, in tissue, it may be as long as 15-30 minutes. Other cleavage products of ACE, seven or

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