binding.

The two independent active sites are positioned near the interface between the two domains. Within each active site, a couple arginine residues are responsible for the enzyme's specificity for dicarboxylic acid substrates: Arg386 interacts with the substrate's proximal (?-)carboxylate group, while Arg292 complexes with the distal (side-chain) carboxylate.

In terms of secondary structure, AST contains both ? and ? elements. Each domain has a central sheet of ?-strands with ?-helices

1.Previous
3.Next