their cytoplasmic tails: CD4 through a Cys-X-Cys/His motif and LAG-3 through an immunoreceptor tyrosine-based inhibition motif like (ITIM-like) motif. LAG-3, which is an inhibitory receptor, is upregulated in activated T cells as a kind of negative feedback loop.

Other interactions

CD4 has also been shown to interact with SPG21, and Uncoordinated-119 (Unc-119).

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