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of the protein Rsr1 in the case of budding, or a patch of Rax1 in mating projections. In the absence of polarity landmarks (i.e. in gene deletion mutants), cells can perform spontaneous symmetry breaking, in which the location of the polarity site is determined randomly. Spontaneous polarization still generates only a single bud site, which has been explained by positive feedback increasing polarity protein concentrations locally at the largest polarity patch while decreasing polarity proteins globally

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