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on the intracellular side.

CLC channels also have dependence on H⁺, but for gating rather than Cl^- exchange. Instead of utilizing gradients to exchange two Cl^- for one H⁺, the CLC channels transport one H⁺ while simultaneously transporting millions of anions. This corresponds with one cycle of the slow gate.

Eukaryotic CLC channels also contain cytoplasmic domains. These domains have a pair of CBS motifs,

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