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sizes (sometimes referred to as "ultrafine grinding"), specialist mills such as the IsaMill are used.

Trituration, for instance, is comminution (or substance breakdown) by rubbing. Furthermore, methods of trituration include levigation, which is the trituration of a powder with a non-solvent liquid, and pulverization by intervention, which is trituration with a solvent that can be easily removed after the substance has been broken down.