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but there was a need to verify that this mechanism could take place in vivo or inside of living cells. Bauer & Metzler (2013) therefore carried out an experiment using a bacterial genome in which they investigated the average time for TF - DNA binding to occur. After analyzing the process for the time it takes for TF's to diffuse across the contour and cytoplasm of the bacteria's DNA, it was concluded that in vitro and in vivo are similar in that the association and dissociation rates of TF's to and from the DNA are similar in both. Also, on

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