(from 2004-2017) performed flybys of many of Saturn's moons including Titan. Cassini-Huygens had its first flyby of Titan in October 2004. For further examples of Cassini flybys of Saturn's moons see Timeline of ''Cassini-Huygens''.

Cassini conducted many flybys at various distances of the moons of Saturn. It achieved 126 flybys of Titan, and its final close flyby was on April 22, 2017 prior to its retirement.