Therefore, it is useful to use both schemes.

The retinal binding lysine

Opsins without the retinal binding lysine are not light sensitive. In cattle rhodopsin, this lysine is the 296th amino acid and thus according to both numbering schemes Lys296^7.43. It is well conserved among opsins, so well conserved that sequences without it were not even considered opsins and thus excluded from large scale phylogenetic reconstructions.

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