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layer, the zona reticularis, produces adrenal androgens, as well as small amounts of estrogens and some glucocorticoids. The zona reticularis has more of the cofactors required for the 17,20-lyase activity of 17?-hydroxylase than zona fasciculata. Therefore, the zona reticularis makes more androgens, mainly dehydroepiandrosterone (DHEA), DHEA sulfate

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