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?-amyloid cleaving enzyme (BACE)) outside the membrane, and second, by gamma secretase (?-secretase), an enzyme complex within the membrane. The sequential actions of these secretases results in A? protein fragments that are released into the extracellular space. In addition to A? peptides that are 40 or 42 amino acids long, several less abundant A? fragments also are generated. A? can be chemically modified in various ways, and the length of the

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