According to the 11th edition of the American Medical Association (AMA) Manual of Style, the following title capitalization rules should be applied:

* Capitalize the first and the last word of titles and subtitles.
* Capitalize nouns, pronouns, adjectives, verbs (including phrasal verbs such as "play with"), adverbs, and subordinate conjunctions (major words).
* Lowercase articles (a, an, the), coordinating conjunctions, and prepositions