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(T-1131>C; in almost complete LD with A-3>G, where the minor allele is associated with about 50% lower gene expression) and rs3135506 (Ser19>Trp; C56>G; alters the signal peptide and influences APOA5 secretion into plasma). There are also a further three common variants (A-3>G, IVS+476 G>A and T1259>C) which are not necessary for haplotype characterisation.Population frequencies of common APOA5 alleles exhibit large interethnic differences. For example, there are about 15% of carriers of the rs66299(C) allele among Caucasians, but the frequency

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