coast in the late 18th century. The presence of small numbers of Makoa people in the region is probably a result of these expeditions. In the last quarter of the 19th century through the beginning of the 20th century, the Tsimihety started returning to the area, settling especially around the trail connecting Mandritsara and Mananara Avaratra, and between the Mananara and Antainambalana rivers.

Ambatosoa was one of the 28 regions created in Madagascar's 1994 decentralization