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<p><a href="page.php?w=activation_energy">activation energy barrier</a> to the transition state is endergonic.  However, the reaction can proceed because having reached the transition state, it rapidly evolves via an exergonic process to the more stable final products.</p>

<p><big> Push </big></p>
<p>Endergonic reactions can be pushed by coupling them to another reaction which is strongly exergonic, through a shared intermediate.</p>

<p>This is often how biological reactions proceed.  For example, on its own the reaction<br/>
:<chem> X + Y -> XY</chem>may</p><p>
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