spherical, lacked dendrites, and secreted the suppressive cytokine IL-10 in vivo. The authors further demonstrated that the number of IL-10 secreting immunosuppressive Langerhans cells, and the amount of IL-10 produced in lesions, corresponded with the severity of histopathology and HPV viral load, providing evidence of an active immunosuppressive mechanism employed by HPV that targets Langerhans cells in vivo.

Dengue fever

Langerhans cells are also the initial target of the virus that

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