Jane's father and uncle avoid bankruptcy. They were married in 1823. Twain was of English and Scots-Irish descent. Only three of his siblings lived beyond childhood: Orion (1825-1897), Pamela (1827-1904), and Henry (1838-1858). His brother Pleasant Hannibal (1828) died at three weeks of age, his sister Margaret (1830-1839) died when Twain was three, and his brother Benjamin (1832-1842) died three years later.

When he was four, Twain's family moved to Hannibal, Missouri,