been questioned whether the last lagging strand primer is placed exactly at the 3'-end of the template and it was demonstrated that it is rather synthesized at a distance of about 70-100 nucleotides which is consistent with the finding that DNA in cultured human cell is shortened by 50-100 base pairs per cell division.

If coding sequences are degraded in this process, potentially vital genetic information would be lost. Telomeres are non-coding, repetitive sequences