PA oligomer may then bind with up to three or four molecules of EF and/or LF, respectively. The cell then endocytoses these assembled complexes and carries them to an acidic compartment in the cell. The low pH encountered in the endosome causes the PA63 pre-channel to convert into a cation-selective channel. EF and LF are driven through the channel by a pH gradient, allowing the enzyme factors to enter the cytosol.

Enzyme function of LF and EF

Once in the cytosol, the

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