(Rb), p107, and p130, which bind to the E2F transcription factors to prevent progression past the G1 checkpoint.

The E2F gene family contains some proteins with activator mechanisms and some proteins with repressing mechanisms. P107 and p130 act as co-repressors for E2F 4 and E2F 5, which work to repress transcription of G1-to-S promoting factors. The third pocket protein, Rb, binds to and represses E2F 1, E2F 2, and E2F 3, which are the E2F proteins with activating abilities.

Positive feedback plays an essential role in regulating

1.Previous
3.Next