and endogenous inhibitors. Angiopoietin-2 works with VEGF to facilitate cell proliferation and migration of endothelial cells.

The general outline of angiogenesis is
* activating signals binding to surface receptors of vascular endothelial cells.
* activated endothelial cells release proteases leading to the degradation of the basement membrane
* endothelial cells are freed to migrate from the existing blood vessels and begin to proliferate to form extensions towards the source of