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(RARalpha) chimera disrupts the normal concentration of PML in nuclear bodies. Administration of arsenic trioxide (As₂O₃) plus all-trans retinoic acid (Tretinoin) causes remission of this leukemia by triggering the bodies' reorganization. As₂O₃ destroys the chimera, allowing new SUMO-1 ubiquitinated PML to relocalize to nuclear bodies. Retinoic acid induces

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