L/g (mL/mg) for a typical globular protein.
* is the concentration of the protein, in the reciprocal units to .

For compact and symmetrical macromolecular solutes (i.e. globular proteins), a weaker dependence of the sedimentation coefficient vs concentration allows adequate accuracy through an approximated form of the previous equation:

During a single ultracentrifuge experiment, the sedimentation coefficient of compounds with a significant concentration dependence changes over time. Using the differential equation for

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