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In a retrospective article, Beadle discussed the status of the one gene-one enzyme hypothesis 10 years after it was proposed. Beadle commented on the Cold Spring Harbor Symposium meeting of biologists in 1951. He noted "I have the impression that the number whose faith in one gene-one enzyme remained steadfast could be counted on the fingers of one hand--with a couple of fingers left over." However, by the early 1960s, the concept that the DNA base sequence of a gene specifies the amino acid

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