form pores in the target cell membrane, can be classified into two families: the cholesterol-dependent toxins and the RTX toxins.

* Cholesterol-dependent cytolysins

Formation of pores by cholesterol-dependent cytolysins (CDC) requires the presence of cholesterol in the target cell. The size of the pores formed by members of this family is extremely large: 25-30 nm in diameter. All CDCs are secreted by the type II secretion

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