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<p>the <a href="page.php?w=World_Health_Organization">World Health Organization</a> formalized a decision to discontinue research into gossypol as a male contraceptive drug. In addition to the other side effects, the WHO researchers were concerned about gossypol's toxicity: the  in primates is less than 10 times the contraceptive dose, creating a small <a href="page.php?w=therapeutic_window">therapeutic window</a>. This report effectively ended further studies of gossypol as a temporary contraceptive, but research into using it as an alternative</p><p>
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