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<p>can be selected by observing how the analyte and internal standard signals change with varying experimental conditions. This includes making adjustments to the sample matrix or instrumentation settings and evaluating whether the selected internal standard is reacting in the same way the analyte is.</p>

<p><big> Example of internal standard method </big></p>
<p>One way to visualize the internal standard method is to create one calibration curve that doesn't use the method and one calibration curve that does. Suppose there are known concentrations of nickel</p><p>
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