adverse events.

Guidelines recommend that it is safe to perform central venous catheter insertion when the platelet count is 20 billion/L or above. The evidence for this is based on observational studies in which bleeding occurred due to procedure error rather than due to the platelet count.

Platelet transfusion thresholds for more major procedures are based on expert opinion alone. Guidelines recommend a threshold of 50 billion/L for major surgery and a threshold of 100 billion/L

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