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intrinsic pathway is caused by cell damage such as DNA damage or UV exposure. This pathway takes place in the mitochondria and is mediated by sensors called Bcl sensors, and two proteins called BAX and BAK. These proteins are found in a majority of higher mammals as they are able to pierce the mitochondrial outer membrane -- making them an integral part of mediating cell death by apoptosis. They do this by orchestrating the formation of pores within the membrane -- essential to the release of cytochrome c. However, cytochrome c is only released

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