is released, U5 shifts from exon to intron, and the U6 binds at the 5' splice site;

:*Complex C (catalytic spliceosome)
:**U4 is released, U6/U2 catalyzes transesterification, making the 5'-end of the intron ligate to the A on intron and form a lariat, U5 binds exon at 3' splice site, and the 5' site is cleaved, resulting in the formation of the lariat;

:*Complex C* (post-spliceosomal complex)
:**U2/U5/U6 remain bound to the lariat, and the 3' site is cleaved and exons are ligated using ATP hydrolysis. The spliced

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