The section from Miami to West Palm Beach is paired with mostly-unsigned State Road 7; many locals in this area generally call US 441 as "State Road 7" instead of US 441. The section from Holopaw to Ocala is paired with unsigned State Road 500. From SR 121 in Gainesville to US 90 in Lake City, it is part of the DeSoto Trail.

Georgia

In Georgia, US 441 continues

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