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<p>studies, because they do not unfold completely within the membranes (the complete unfolding would require breaking down too many ?-helical <a href="page.php?w=H-bond">H-bond</a>s in the nonpolar media). On the other hand, these proteins easily misfold, due to non-native aggregation in membranes, transition to the <a href="page.php?w=molten_globule">molten globule</a> states, formation of non-native <a href="page.php?w=disulfide_bonds">disulfide bonds</a>, or unfolding of peripheral regions and nonregular loops that are locally less stable.</p>

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