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One of the predicting modes of recognition used for recognition is through a duplex invasion. Within mixed A-T/G-C dsDNA sequence is targeted by a pair of pseudo-complementary (pc) PNAs which are able to bind to dsDNAs via double invasion through the simultaneous formation of diaminopurine (D) and thiouracil (U^s) which substitute for adenine and thymine, respectively. The pc PNA pair form a D-T and U^s -A and G-C or C-G Watson-Crick paired PNA-DNA helix with each of complementary DNA strands. Another form of recognized duplex

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