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<p><a href="page.php?w=amylin">amylin</a> and <a href="page.php?w=ghrelin">ghrelin</a>.</p>

<p><big>Clinical significance</big></p>
<p>Rare and slow growing <a href="page.php?w=carcinoid">carcinoid</a> and non-carcinoid tumors develop from these cells. When a tumor arises it has the capacity to secrete large volumes of hormones.</p>

<p><big>History</big></p>
<p>The very discovery of hormones occurred during studies of how the digestive system regulates its activities, as explained at <a href="page.php?w=Secretin">Secretin § Discovery</a>.</p>

<p><big> Other organisms </big></p><p>
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