and autophagic cargo primarily happens within these transient structures--endolysosomes and autolysosomes--under normal physiological conditions.

Endocytosed materials--such as complex lipids, membrane proteins, and polysaccharides--enter the endocytic pathway; moving first in early endosomes, then in late endosomes containing intraluminal vesicles (also referred to as multivesicular bodies, MVBs). Then they interact with lysosomes, either via full fusion, or via "kiss-and-run" events where brief