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Mehmed Pasha, defeated Kara Khan and Safavid control in the region crumbled. The Ottomans besieged Mardin again, which resisted under the command of Kara Khan's brother, Sulayman Khan. After the Battle of Marj Dabiq in August 1516, Biyikli Mehmed Pasha returned with reinforcements from Syria and finally forced the city's surrender in late 1516 or early 1517. After this, Mardin was administered by a governor directly appointed under the Ottoman Sultan's authority.

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