to see where replication was taking place. The first conclusive observations of bidirectional replication was from studies of B. subtilis. Shortly after, the E. coli chromosome was also shown to replicate bidirectionally.

* See Figure 4 of D. M. Prescott, and P. L. Kuempel (1972): A grain track produced by an E. coli chromosome from cells labeled for 19 min with [3H] thymine, followed by labeling for 2.5 min with [3H]thymine and ['H]thymidine. .

The E. coli DNA polymerase III holoenzyme

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