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causes cortical reaction to occur. Cortical granules inside the secondary oocyte fuse with the plasma membrane of the cell, causing enzymes inside these granules to be expelled by exocytosis to the zona pellucida. This in turn causes the glycoproteins in the zona pellucida to cross-link with each other -- i.e. the enzymes cause the ZP2 to hydrolyse into ZP2f -- making the whole matrix hard and impermeable to sperm. This prevents

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