I got arrested because of you! Tommy: Tough shit, dude, you knew you might get arrested when you chose to come with me.) Note that in this case, as in many cases with the term, tough shit is often said as a way of pointing out someone's fault in his/her own current problem. It's also common to express annoyance by simply saying Shit.

A shitload of something is a large quantity, especially something unpleasant or disgusting. The boss dumped a shitload of extra work for me this week. A shit sandwich