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Thus, myosin II has two heads. In smooth muscle, there is a single gene (MYH11) that codes for the heavy chains myosin II, but there are splice variants of this gene that result in four distinct isoforms. Also, smooth muscle may contain MHC that is not involved in contraction, and that can arise from multiple genes.
* Myosin II also contains 4 light chains (MLC), resulting in 2 per head, weighing 20 (MLC₂₀) and 17 (MLC₁₇) kDa.

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