SNAP-25, and between the C2B domain and the "synprint" (synaptic protein interaction) motif of the pore-forming subunit of voltage-gated calcium channels. The C2B domain regulates also the recycling step of synaptic vesicles by binding to the clathrin assembly protein, AP-2.

Plasticity and Learning

Synaptotagmin variants have been implicated in the enhancement of neural connections, leading to long-term potentiation

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