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1st Lord of Villoria, son of García Álvarez de Toledo, 1st Duke of Alba, and his first wife María de Rojas, and had the following children:
* María Colón de Toledo (c. 1510 - ?), married to Sancho Folch de Cardona, 1st Marquess of Guadalest
* Luis Colón, 1st Duke of Veragua (c. 1519/1520/1522 - 1572), married

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