while Alkbh5 knockout mice have impaired fertility. These two facts reflect how important the proper regulation of the m⁶A modification is for normal body function. Moreover, mutations in FTO can lead to developmental failures, brain atrophy and physiological disorders in adulthood.

Role in the life-cycle of mRNA

mRNA methylation is important throughout the entire life-cycle of the mRNA, starting with the alternative polyadenylation (APA) of some transcripts. m⁶A

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