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(cancer) is due to a variety of mechanisms. The two most common are humoral hypercalcaemia of malignancy and local osteolytic hypercalcaemia due to bony metastasis. Humoral hypercalcaemia of malignancy involves the tumour releasing a hormone which increases calcium mobilisation (most commonly parathyroid hormone-related protein (PTHrP)) into the circulation. PTHrP acts similarly to parathyroid hormone in that it binds to the parathyroid hormone 1 receptors

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