Function

The AER acts to:

*Maintain the limb mesenchyme in a mitotically active state and focused on its task - the distal outgrowth of the limb. This is achieved by secretion of FGF8, which signals the limb mesodermal cells to continue proliferation, and secreting FGF10, which winds up maintaining the AER.
*Sustain expression of the molecules that establish the anterior-posterior axis. The FGFs

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